I use numerous software and external gear both midied up at the same time.My applications are Reason 3.0- Pro Tools 7.0- Sound Forge -Acid- Sonar -DP4-Nuendo-Logic Audio-Garage Band-My External Gear-Every Ensoniq Sampler EPS ASR-X-10-16 plus 4-MPC-60-4000-O.G SP 1200-SP 202-Original *808 Roland-And all kind of Keyboards ranging from Roland ,Yamaha to Moog for synths and bass.That's aboout it a simple set-up but cool.