Face it, 50 Cent knows how to sell records, and it's not by diluting songs with G-Unit guest appearances. He has access to numerous star producers (and even those within the G-Unit camp are good) and can market any piece of shit album to at least go platinum. It can't be any worse than Eminem's efforts. And we all know how much 50 worships Pac, and I'd bet 50 would be willing to invest more money into this album alone (hypothetically speaking) than Amaru has in all recent posthumous efforts combined.
The only downsides are inevitable G-Unit appearances (but 50 knows better than to do so with too many songs, unlike Eminem) and the removal of any existing Mobb Deep disses.
EDIT: I just thought of another downside, which is 50 singing on hooks. But hey, it can't be any worse than Eminem's gay ass singing on "Soldier like Me," right? Sing on.